Iroquois homeobox gene 3 establishes fast conduction in the cardiac His-Purkinje network
نویسندگان
چکیده
منابع مشابه
His-Purkinje conduction findings after cardiac surgery in children.
Conduction abnormalities of the His-Purkinje (HP) system are common sequelae of surgical repair of heart defects. Standard electrophysiologic recordings may fail to demonstrate abnormalities of the HP system when routine intervals are measured. When the conduction system is stressed, certain HP features that may indicate latent conduction disease within the HP system can be revealed. These feat...
متن کاملHis-Purkinje conduction during retrograde stress.
The pattern of retrograde His-Purkinje conduction was evaluated in 28 patients using ventricular extrastimuli. In each patient progressive prolongations of His-Purkinje conduction (S2H2) which appeared as ventricular extrastimuli were induced at closer coupling intervals (S1S2). There was an inverse linear relationship of S2H2 to S1S2 which was cycle length-dependent: i.e., at any S1S2 interval...
متن کاملHomeobox protein Hop functions in the adult cardiac conduction system.
Hop is an unusual homeobox gene expressed in the embryonic and adult heart. Hop acts downstream of Nkx2-5 during development, and Nkx2-5 mutations are associated with cardiac conduction system (CCS) defects. Inactivation of Hop in the mouse is lethal in half of the expected null embryos. Here, we show that Hop is expressed strongly in the adult CCS. Hop-/- adult mice display conduction defects ...
متن کاملEffect of verapamil on infranodal conduction in patients with baseline His-Purkinje conduction delay.
mented as causes of angina in patients who had normal coronary arteriograms.’ Unfortunately, coronary vasodilatory flow reserve before or during this study was not measured. One would anticipate significant abnormality of the vasodilatory response. Syndrome X, a constellation of findings of chest pain, myocardial ischemia, ECG abnormalities, and normal coronary arteries, is the most likely diag...
متن کاملSupernormal excitability and conduction in the His-Purkinje system of the dog.
The electrophysiological characteristics of the period of supernormal excitability and supernormal conduction were investigated in the isolated canine His-Purkinje system. Strength-interval curves were determined as the minimum transmembrane current required to bring the impaled fiber to threshold potential following a conducted action potential. During the period of supernormal excitability, 1...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2011
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.1106911108